How can a small startup handle time zone differences between Europe and the United States without slowing down?

Start by defining a clear overlap window where everyone is available, for example two or three hours in the European late afternoon and US morning. Reserve this slot for decisions, clarifications, and work that truly needs synchronous discussion. Outside that window, expect most collaboration to be asynchronous through tickets, written updates, and short recorded videos. Train people to leave context rich messages so colleagues can pick up work without another meeting. When done well, this creates a smooth relay effect instead of a chain of blockers waiting for someone to wake up.