Deno is built for better runtime security, with permission controls by default, and improves modern tooling - with built-in TypeScript support, a single executable, and no config needed for many use cases. Node.js, while mature and robust with a massive ecosystem, requires add-ons for tighter security, stricter permissions, and out-of-the-box TypeScript. For teams starting now, Deno is considered safer and simpler, though Node supports more real-world libraries.
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