Node.js fits real-time, high-concurrency backends such as chat apps and streaming APIs. Flask fits smaller Python services where a lightweight, unopinionated framework matters more than raw concurrency. Node.js, first released in 2009, runs on the V8 JavaScript engine and handles I/O through a single-threaded event loop backed by libuv, while Flask, released in 2010, is a WSGI microframework built on Werkzeug and Jinja2 that processes one request per worker by default.
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