SpatiaLite fits lightweight, embedded, or mobile GIS work; PostGIS fits multi-user systems where several people or services read and write the same spatial data at once. SpatiaLite is a spatial extension for SQLite created by Alessandro Furieri, first released in 2008, and it runs inside the application as a library rather than as a separate service. PostGIS is a spatial extension for PostgreSQL, so it only works with a running PostgreSQL server that clients connect to.
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