Early FastAPI projects should avoid mixing synchronous and asynchronous route handlers without understanding the performance implications, as blocking synchronous calls inside async routes can block the event loop. Do not skip Pydantic model validation in favour of raw request parsing, since Pydantic is FastAPI's primary security boundary for input data. Do not deploy FastAPI without a production ASGI server like Uvicorn behind Gunicorn, as the development server is not suitable for handling production traffic.
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