Express.js, built on Node.js, is fast and unopinionated, and it relies on JavaScript skills familiar to many web teams - making delivery fast, especially for teams used to JS and npm tooling. Flask is also quick for prototyping and requires little setup, offering flexibility in Python. For teams fluent in JS, Express.js is slightly faster - from setup to launch. If Python skills dominate, Flask keeps early projects rapid. The choice depends on your team's language strengths.
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