FastAPI is built with modern async Python, delivers faster performance, auto-generates interactive API docs with OpenAPI/Swagger, and offers type hints with validation powered by Pydantic. Flask is simple, battle-tested, and flexible, but lacks async support and out-of-the-box API typing/docs. For speed, structure, and modern Python best practices, FastAPI excels. Flask is reliable for quick prototyping or traditional Python web apps.
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